Melanogenesis is a pigmentation issue that is commonly faced by mature individuals. It may show a different color on your skin hence sometimes misinterpreted as sunburned skin or freckles. However, understanding melanogenesis will enable you to see that it is different from the previously mentioned skin problems. It also requires an Individual to focus on certain remedies that are appropriate for it.
Essential oils are known to be administered in treating melanogenesis. Different oils have been seen in some articles that may lead you to wonder if they are really effective in Melanogenesis treatment. However, it is important to know which Essential oil is legitimately effective in regulating Melanin cells. While there are oils that have been speculated that can be used for melanogenesis, it is important to be reminded that some are not supported by research. Cosmetic argan oil is the appropriate oil for melanogenesis because research confirmed its effects in regulating melanin cells. To confirm the impact of cosmetic argan oil on melanogenesis, a 2013 in vitro study that investigated the inhibitory potential of cosmetic argan oil on B16 murine melanoma cells, a type of pigment cell has been used as a reference. This post discusses why Cosmetic Argan oil is proven to be the best oil for Melanogenesis.
Cosmetic argan oil compounds
Major fatty acids in Cosmetic argan oil are oleic acid, linoleic acid, palmitic, and stearic acid. Carotenoids, triterpene alcohols, and xanthophylls are also legitimately found in argan oil. Other chemicals in the oil are sterols. Types of sterol exhibited in argan oil are sitosterol, spinasterol, schottenol, and -sitosterol. However, the most important component of Cosmetic argan oil that makes it effective in Melanogenesis is tocopherols. Alpha-tocopherol also known as Vitamin E is the main tocopherol in argan oil.
Two reasons for the depigmenting effect of cosmetic argan oil
1. vitamin E and Tocopherol effect on melanogenic enzymes
The depigmenting effect of cosmetic argan oil is due to tocopherols. It can inhibit melanogenic enzymes tyrosinase (TYR), and dopachrome tautomerase (DCT) expressions. Its ability to inhibit melanin biosynthesis controls the number of melanin cells.
Enzymes are important in controlling melanogenesis. Melanin biosynthesis occurs at melanosomes that contain the enzymes tyrosinase (TYR), tyrosinase-related protein 1 (TRP1), and dopachrome tautomerase (DCT). These three major enzymes have the ability: to catalyze Melanin biosynthesis.
The amount of these enzymes in the cells is important during the production of pigment cells or melanin because it can limit the overproduction of melanin leading to melanogenesis. Chemical compounds can inhibit or activate melanogenic enzymes and this affects regulating the pigmentation of the skin.
The 2013 In vitro test elicited the effect of cosmetic argan oil on depigmentation because the expression of melanogenic enzymes dopachrome tautomerase (DCT), tyrosinase (TYR) and tyrosinase-related protein 1 (TRP1) decreased after 72 hrs of treatment. The fatty acids of argan oil are important in regulating the activities of tyrosinase. Linoleic acid decreases tyrosinase activity, while palmitic acid increases it.
2. vitamin E as an antioxidant and its power against hyperpigmentation
The coacting effect of all the argan oil components also contributes to the effective treatment of melanogenesis. Post-inflammatory hyperpigmentation occurs when the epidermal cells have been damaged. This happens when lipid peroxidation has been triggered due to UV radiation exposure. Argan oil is an effective antioxidant due to its components. Tocopherol particularly the alpha-tocopherol or vitamin E helps in lipoperoxidation protection. Apha-tocopherol commonly known as vitamin E can whiten the skin. The combination of Vitamins E and C even makes it more effective in dealing with hyperpigmentation. This is because they inhibit the production of melanogenic cytokines by serving as radical scavengers by trapping peroxyradical caused by UV-B.
Incubation treatment time
The study proved that argan oil indeed can decrease tyrosinase. However, 4 hours of treatment with argan oil on B16 melanoma cells does ot result in an immediate decrease. To see the most inhibitory effect, melanoma cells must be incubated for 48 to 72 hours
Concentration and dilution
The 2013 in-vitro result showed the following:
At 1/10000 dilution, argan oil can already cause a depigmenting effect.
At 1/1000 v/v, there was a significant decrease in tyrosinase, and DCT expression but not TRP1. This result showed after 72 hours of incubation treatment.
At 1/100 dilution, there was no cytotoxic effect on argan-treated B16 cells, but there was a decrease in melanin content after 72 hours. There was a slight decrease in the cell count and cell viability.
Note:
This is my 2nd Official post about melanogenesis. The First post I’ve written about melanogenesis is an Extract. In the first post, I clarified the misconception that the substance used in melanogenesis is an extract and Not the Oil of Ylang ylang.
This 2nd post about melanogenesis confirms that Cosmetic argan oil is truly proven to be effective in healing melanogenesis.
Ps. Please note that my focus is genuine Essential oils, and I don’t write about synthetic oils.
Focus on the Essentials
Reference:
- Villareal M.O., Kume S., Bourhim T., Bakhtaoui F.Z., Kashiwagi K., Han J., Gadhi C., Isoda H. Activation of MITF by Argan Oil Leads to the Inhibition of the Tyrosinase and Dopachrome Tautomerase Expressions in B16 Murine Melanoma Cells. Hindawi Publishing Corporation. 2013 http://dx.doi.org/10.1155/2013/340107
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